Vaccines for treatment of breast cancer

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Unlike traditional vaccines, which act to prevent disease, breast cancer vaccines are being developed as a treatment, targeting existing cancer cells with the aim of stopping tumour growth. Dendritic cells are part of the immune system and monitor our bodies for potentially harmful intruders. Producing a dendritic cell vaccine requires the patient to give a sample of blood, from which dendritic cells will be isolated and matured outside of the body.

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A cancer vaccine is a vaccine that either treats existing cancer or prevents development of a cancer. Vaccines that treat existing cancer are known as therapeutic cancer vaccines. Some researchers claim that cancerous cells routinely arise and are destroyed by the immune system immunosurveillance ; [1] and that tumors form when the immune system fails to destroy them.

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Breast cancer is responsible for an estimated 40, deaths per year in the US, though that number has had a downward trend over the last few years because of early detection and aggressive treatment. The development of a new vaccine could drive down that mortality rate even further. A small, phase 1 study using 14 individuals with stable yet metastatic breast cancer has shown that a vaccine is safe.

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Breast cancer BC is a persistent global challenge for its high frequency in women although it seldom occurs in mendue to the large diffusion of risk factors and gene mutations, and for its peculiar biology and microenvironment. To date, BC can benefit from different therapeutic strategies involving surgery, ablation, chemotherapy, radiotherapy, and more specific approaches such as hormone therapy and the administration of various substances impairing cancer growth, aggressivity, and recurrence with different modalities. BC immunogenicity was latterly proven, so the whole immunotherapy field for BC is still at a very early stage.

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Vaccines contain cells or antigens which, when injected into the body, cause an immune response with the production of antibodies and immune lymphocytes T-cells that specifically attack the injected cell or antigen. These antibodies and immune lymphocytes normally attack and kill invaders such as bacteria, viruses and parasites. Vaccines have been widely used to control and even eradicate infectious diseases such as polio and smallpox.

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A vaccine that prevents the recurrence and development of breast and ovarian cancers could become available in less than a decade, according to researchers at the Mayo Clinic in Jacksonville, Florida. The researchers developed an immunotherapy treatment that trains the immune system to recognize and kill breast cancer cells. Based on the results of early-stage clinical trials, the vaccine seems to have successfully removed cancer cells in one patient, and another is showing positive results.

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A trial is underway for a breast cancer vaccine. Scientists are hoping this latest immunotherapy will help keep patients from developing cancer again. Currently, the only vaccine designed to prevent cancer is the HPV vaccine.

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Vaccinations are administered every 2 weeks for 6 weeks and then monthly for 3 months. GM-CSF is administered with the vaccination, then every 12 hours for 7 days. Monthly vaccinations may continue as long as response is shown.

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When Leisha Emens decided to specialize in treating breast cancer patients, her goal was to bring new ideas to the field. As a physician-scientist, Emens continually works on innovative strategies to beat one of the most common causes of cancer for women and a cancer that still takes far too many lives. The vaccine is injected under the skin and then it goes to work by drawing the attention of the immune cells, known as dendritic cells, to the vaccine injection site.

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New vaccines, targeting the most deadly forms of cancer in the United States, are undergoing trials across the country and being heralded as promising breakthroughs in the growing field of immunotherapy — immune-based treatments that many in the medical research community believe is one of the most promising ways to treat, cure and prevent cancer. In the last few years, the number of clinical trials in this field has exploded, along with the flurry of money from Big Pharma and investors, stirring optimism in the fight against cancer. Over the next decade it is predicted that immunotherapies will be the backbone of cancer treatments in 60 percent of cancer types. According to the American Cancer Society, cancer is the second most common cause of death in the United States, exceeded only by heart disease.


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